Synthesis of Aminoquinoline??Based Aminoalcohols and Oxazolidinones and Their Antiplasmodial Activity

F Kobarfard, V Yardley, S Little…

Index: Kobarfard, Farzad; Yardley, Vanessa; Little, Susan; Daryaee, Fereidoon; Chibale, Kelly Chemical Biology and Drug Design, 2012 , vol. 79, # 3 p. 326 - 331

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Citation Number: 11

Abstract

Novel aminoquinoline b-aminoalcohol and oxazolidinone derivatives were designed, synthesized, and evaluated for in vitro antiplasmodial activity against a chloroquine- sensitive (3D7) and chloroquine-resistant (K1) strains of Plasmodium falciparum. A few b- aminoalcohol derivatives were more potent than chloroquine against chloroquine-sensetive Plasmodiums. The potency of these derivatives decreased against chloroquine-resistant ...