Copper-catalysed N-arylation of pyrrole with aryl iodides under ligand-free conditions

…, F Wu, Y Liu, J Xie, B Dai, Z Zhou

Index: Liu, Lili; Wu, Fengtian; Liu, Yan; Xie, Jianwei; Dai, Bin; Zhou, Zhuoqiang Journal of Chemical Research, 2014 , vol. 38, # 3 p. 180 - 182

Full Text: HTML

Citation Number: 0

Abstract

A simple, inexpensive and ligand-free copper-catalysed N-arylation of pyrrole with aryl iodides has been developed giving N-arylated products in moderate to excellent yields. The catalyst loading is relative low (5 mol%) and the catalyst system was stable in air. ... Keywords: copper, ligand-free, N-arylation, pyrrole, aryl iodides ... Pyrrole-containing heterocycles are ubiquitous in natural and well-represented among the desirable structures of modern medicinal ...

Related Articles:

New strategy for the synthesis of N-aryl pyrroles: Cu-catalyzed C–N cross-coupling reaction of trans-4-hydroxy-l-proline with aryl halides

[Reddy, V. Prakash; Kumar, A. Vijay; Rao, K. Rama Tetrahedron Letters, 2011 , vol. 52, # 7 p. 777 - 780]

Tungstophosphoric acid supported on silica gel (H3PW12O40/SiO2) as an eco-friendly, reusable and heterogeneous catalyst for the synthesis of pyrroles in solution …

[Jafari; Mahmoudi; Mirjalili Journal of the Iranian Chemical Society, 2011 , vol. 8, # 3 p. 851 - 856]

Reductive One Batch Synthesis of N-Substituted Pyrrolidines from Primary Amines and 2, 5-Dimethoxytetrahydrofuran

[Verardo, Giancarlo; Dolce, Anna; Toniutti, Nicoletta Synthesis, 1999 , # 1 p. 74 - 79]

Novel approach for the synthesis of N-substituted pyrroles starting directly from nitro compounds in water

[Das, Biswanath; Shinde, Digambar Balaji; Kanth, Boddu Shashi; Kumar, Jayprakash Narayan Synthetic Communications, 2012 , vol. 42, # 4 p. 548 - 553]

More Articles...