Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1, 2] thiazolo [5, 4-d] pyrimidin-6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin …
ME Theoclitou, B Aquila, MH Block…
Index: Journal of Medicinal Chemistry, , vol. 54, # 19 p. 6734 - 6750
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Abstract
... Journal of Medicinal Chemistry. ... 4-oxo-[1,2]thiazolo[5,4-d]pyrimidin-6-yl)-2-methylpropyl]-4- methylbenzamide (AZD4877), from a series of novel kinesin spindle protein (KSP) inhibitors, as exhibiting both excellent biochemical potency and pharmaceutical properties suitable for ...
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