A new preparation of difunctionalized enamines from thioamides using silver (I) carbonate

D Brillon, G Sauve

Index: Brillon, Denis; Sauve, Gilles Journal of Organic Chemistry, 1990 , vol. 55, # 7 p. 2246 - 2249

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Citation Number: 9

Abstract

Bn II interesting biological implications. The condensation of malononitrile with N-methyl thiolactam la in presence of silver carbonate6,'in acetonitrile at 25 “C gave enamine 2a (88%, Table I). No reaction was observed with monoprotic thiolactam lb, proving that neutral silver complexes are unreactive. These conditions are simpler3 and the reactions are faster than those with silver tetrafluoroborate or mercury (I1) trifluoroacetate followed by the ...