Design and synthesis of N-2, 6-difluorophenyl-5-methoxyl-1, 2, 4-triazolo [1, 5-a]-pyrimidine-2-sulfonamide as acetohydroxyacid synthase inhibitor

CN Chen, LL Lv, FQ Ji, Q Chen, H Xu, CW Niu…

Index: Chen, Chao-Nan; Lv, Li-Li; Ji, Feng-Qin; Chen, Qiong; Xu, Hui; Niu, Cong-Wei; Xi, Zhen; Yang, Guang-Fu Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 8 p. 3011 - 3017

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Citation Number: 42

Abstract

Triazolopyrimidine-2-sulfonamide belongs to a herbicide group called acetohydroxyacid synthase inhibitors. With the aim to discover new triazolopyrimidine sulfonanilide compounds with high herbicidal activity and faster degradation rate in soil, the methyl group of Flumetsulam (FS) was modified into a methoxy group to produce a new herbicidal compound, N-2, 6-difluorophenyl-5-methoxy-1, 2, 4-triazolo [1, 5-a] pyrimidine-2- ...