Studies of the Selective O-Alkylation and Dealkylation of Flavonoids. XXII. A Convenient Method for Synthesizing 3, 5, 7-Trihydroxy-6-methoxyflavones.

…, K Shibata, K Yamashita, Y KAWAMURA…

Index: Horie, Tokunaru; Shibata, Kenichi; Yamashita, Kazuyo; Kawamura, Yasuhiko; Tsukayama, Masao Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 3 p. 446 - 451

Full Text: HTML

Citation Number: 27

Abstract

The demethylation of 3, 4-dioxygenated 6-methoxy-2-isopropoxyacetophenones was studied and it was found that 4-benzyloxy-6-hydroxy-3-methoxy-2-isopropoxyacetophenone was easily obtained from 4-benzyloxy-3, 6-dimethoxy-2-isopropoxyacetophenone by selective demethylation with anhydrous aluminum bromide-sodium iodide in acetonitrile. The acetophenone was converted into 7-benzyloxy-3-hydroxy-6-methoxy-5- ...