Asymmetric synthesis of both enantiomers of 2-(dimethylamino)-1-[3-methoxy-2-(1-methylethoxy) phenyl] ethanol

…, M Barras, I Angel, G Georges, P Ochsenbein

Index: Philippo; Fett; Bovy; Barras; Angel; Georges; Ochsenbein European Journal of Medicinal Chemistry, 1997 , vol. 32, # 11 p. 881 - 888

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Citation Number: 3

Abstract

Both enantiomers of 2-(dimethylamino)-1-[3-methoxy-2-(1-methylethoxy) phenyl) ethanol were synthetized by a stereoselective route and evaluated in vitro for their uroselectivity in comparison with other α1-adrenoceptor agonists. The most potent enantiomer was structurally characterized by X-ray crystallographic analysis.