Structural Insight into the Unique Binding Properties of Pyridylethanol (phenylethyl) amine Inhibitor in Human CYP51

…, D Rozman, S Golič Grdadolnik

Index: Korosec, Tina; Grdadolnik, Joze; Urleb, Uros; Kocjan, Darko; Grdadolnik, Simona Golic Journal of Organic Chemistry, 2006 , vol. 71, # 2 p. 792 - 795

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Abstract

Sterol 14α-demethylase (CYP51) is the main drug target for the treatment of fungal infections. The discovery of new efficient fungal CYP51 inhibitors requires an understanding of the structural requirements for selectivity for the fungal over the human ortholog. In this