Glyoxyl analogs of indole phytoalexins: Synthesis and anticancer activity

…, J Mojžiš, R Mezencev, P Pazdera…

Index: Kutschy, Peter; Sykora, Andrej; Curillova, Zuzana; Repovska, Maria; Pilatova, Martina; Mojzis, Jan; Mezencev, Roman; Pazdera, Pavel; Hromjakova, Tatiana Collection of Czechoslovak Chemical Communications, 2010 , vol. 75, # 8 p. 887 - 903

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Citation Number: 5

Abstract

Abstract Glyoxyl analogs of indole phytoalexins brassinin, 1-methoxybrassinin, brassitin, 1- methoxybrassitin and 1-methoxybrassenin B were prepared, using (1H-indol-3-yl)-,(1- methoxyindol-3-yl)-and [1-(2, 3, 4, 6-tetra-O-acetyl-β-D-glucopyranosyl) indol-3-yl] glyoxyl chlorides as starting compounds. Synthesized products were examined for their antiproliferative activity against human cancer cell lines Jurkat (T-cell acute lymphoblastic ...