Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives

J Liu, R Cao, Q Wu, C Ma, Z Wang, W Peng…

Index: Liu, Jinbing; Cao, Rihui; Wu, Qifeng; Ma, Chunming; Wang, Zihou; Peng, Wenlie; Song, Huacan European Journal of Medicinal Chemistry, 2009 , vol. 44, # 4 p. 1737 - 1744

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Citation Number: 15

Abstract

A series of novel 4-alkylphenyl β-aldehyde ketones and their derivatives were designed and synthesized on the basis of the chemical structures of Houttuynin and β-lactam antibiotics. Antibacterial activities of these compounds were investigated. The results demonstrated that most of the compounds tested had moderate antibacterial activities against Gram-positive pathogen Staphylococcus aureus (ATTC-25923) than Houttuynin, and Gram-positive ...

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