Synthesis and antioxidant activities of 3, 5-dialkoxy-4-hydroxycinnamamides

…, JP Kim, Y Konishi, JY Kong, NS Park, YS Jung

Index: Kang, Tae-Souk; Jo, Hyang-Ok; Park, Woo-Kyu; Kim, Jong-Pyung; Konishi, Yasuo; Kong, Jae-Yang; Park, No-Sang; Jung, Young-Sik Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 5 p. 1663 - 1667

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Citation Number: 10

Abstract

A series of 3, 5-dialkoxy-4-hydroxycinnamamides 6 and 7 was synthesized, and their antioxidant activity was assessed using the thiobarbituric acid reactive substance (TBARS) assay. Interestingly, cinnamamides with longer alkoxy groups on the C-3 and C-5 positions display enhanced inhibition, and most of the compounds in the series tested exhibit excellent lipid peroxidation inhibitory activities. Some cinamamides bearing hexyloxy or 2, ...