Nucleoside phosphitylation using ionic liquid stabilised phosphorodiamidites and mechanochemistry

K Crossey, C Hardacre, ME Migaud

Index: Crossey, Kerri; Hardacre, Christopher; Migaud, Marie E. Chemical Communications, 2012 , vol. 48, # 98 p. 11969 - 11971

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Abstract

Within the field of carbohydrate and nucleotide chemistry, novel methods are currently being widely explored for the derivatisation of sugar moieties where traditional methods are hampered by challenging syntheses which require multi-step processes and selective functional group manipulations. 1 In this regard, mechanochemistry has been used to overcome issues such as reagent solubility and reactivity, 2 while ionic liquids (ILs) have been shown to stabilise ...