Transacetalization Reaction of Acetals by Lactic Acid. Diastereoselective Synthesis of 2-Substituted 5-methyl-1, 3-dioxolan-4-ones

JY Ortholand, N Vicart, A Greiner

Index: Ortholand, Jean-Yves; Vicart, Nicolas; Greiner, Alfred Journal of Organic Chemistry, 1995 , vol. 60, # 6 p. 1880 - 1884

Full Text: HTML

Citation Number: 16

Abstract

In connection with work on the synthesis of optically pure a-hydroxy-/I-keto esters of biological interest, we developed a new procedure for highly diastereoselective preparation of 2, 2-disubstituted 5-methyl-1, 3-dioxolan-4-ones. Related dioxolanones have been widely used recently for several applications,'including the 1, 3 chirality transfer principle. 2 Two general methods of formation3 of these chiral building blocks were known at the ...