Transformation of a series of saturated isomeric steroidal diols by Aspergillus tamarii KITA reveals a precise stereochemical requirement for entrance into the …

…, C Collins, HT Dodd, C Dedi, SJ Koussoroplis

Index: Hunter, A. Christy; Collins, Catherine; Dodd, Howard T.; Dedi, Cinzia; Koussoroplis, Salome-Juliette Journal of Steroid Biochemistry and Molecular Biology, 2010 , vol. 122, # 5 p. 352 - 358

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Citation Number: 10

Abstract

Four isomers of 5α-androstan-3, 17-diol have been transformed by the filamentous fungus Aspergillus tamarii, an organism which has the ability to convert progesterone to testololactone in high yield through an endogenous four step enzymatic pathway. The only diol handled within the lactonization pathway was 5α-androstan-3α, 17β-diol which, uniquely underwent oxidation of the 17β-alcohol to the 17-ketone prior to its Baeyer– ...