Bioorganic & medicinal chemistry letters

Inactivation of S-adenosylhomocysteine hydrolase with haloethyl and dihalocyclopropyl esters derived from homoadenosine-6′-carboxylic acid

G Guillerm, M Muzard, C Glapski

Index: Guillerm, Georges; Muzard, Murielle; Glapski, Cedric Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 23 p. 5799 - 5802

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Citation Number: 9

Abstract

In a search for new inhibitors that exploit 5′–6′'hydrolytic activity'of AdoHcy hydrolase, a new series of haloethyl and dihalocyclopropyl esters 2–3 were designed and their interaction with the enzyme studied. Incubation of the enzyme with 2–3 resulted in time-and concentration-dependent inactivation of AdoHcy hydrolase as well as almost total depletion of its NAD+ content. Further results indicated that the 'oxidative'but not the 'hydrolytic' ...