3-[(6-Arylamino) pyridazinylamino] benzoic acids: design, synthesis and in vitro evaluation of anticancer activity

…, NA Khalil, EM Ahmed, KO Mohamed

Index: Abouzid, Khaled A. M.; Khalil, Nadia A.; Ahmed, Eman M.; Mohamed, Khaled Omar Archives of Pharmacal Research, 2013 , vol. 36, # 1 p. 41 - 50

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Citation Number: 6

Abstract

Abstract A series of novel substituted 3, 6-disubstituted pyridazines based on the structure of vatalanib (PTK787) were designed and synthesized. The cytotoxicity of the final compounds was tested in vitro on HT-29 colon cancer cell line. Compounds 2a and 2b with 4- chlorophenylamino moiety, exerted the highest cytotoxic activity with IC 50 values equal to 15.3 and 3.9 μM respectively. The most promising compound, 2b, was found to be about ...