Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands

Y Huang, RR Luedtke, RA Freeman…

Index: Yang, Biao; Johnston Jr., Douglas E.; Luedtke, Robert R.; Hammond, Philip S.; Mach, Robert H. Medicinal Chemistry Research, 1998 , vol. 8, # 3 p. 115 - 131

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Citation Number: 31

Abstract

A series of naphthamides were synthesized, and the affinities of these compounds were determined for dopamine D2 and D3 receptors using radioligand binding techniques. The naphthamide compounds that were prepared include N-(1-alkylpiperidin-4-yl)-4-bromo-1-