Tetrahedron

An expedient protocol of the Biginelli dihydropyrimidine synthesis using carbonyl equivalents

K Singh, J Singh, PK Deb, H Singh

Index: Singh, Kamaljit; Singh, Jasbir; Deb, Prasant K.; Singh, Harjit Tetrahedron, 1999 , vol. 55, # 44 p. 12873 - 12880

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Citation Number: 84

Abstract

A one-pot condensation of perhydro-1, 3 heterocycles-aldehyde equivalents with ethyl acetoacetate and ureas provides a convenient synthesis of the title compounds with a variety of substituents at C-4. Yields are equivalent or significantly higher than the conventional methods.

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