Chemistry–A European Journal

Spiropyran photoswitches in the context of DNA: Synthesis and photochromic properties

C Brieke, A Heckel

Index: Brieke, Clara; Heckel, Alexander Chemistry - A European Journal, 2013 , vol. 19, # 46 p. 15726 - 15734

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Citation Number: 18

Abstract

Abstract A new design is presented for the incorporation of spiropyran photoswitches into nucleic acids by oligonucleotide solid phase synthesis. This design enables interaction of the 6-nitrospirobenzopyran (NitroBIPS) photoswitch with the adjacent nucleobases and leaves the photochemical properties of NitroBIPS intact. UV/Vis spectroscopy and HPLC revealed that NitroBIPS incorporated into DNA consists of up to 40% merocyanine in its ...