Organocatalyzed conjugate addition of carbonyl compounds to Nitrodienes/Nitroenynes and synthetic applications

…, A Quintard, N Krause, A Alexakis

Index: Belot, Sebastien; Quintard, Adrien; Krause, Norbert; Alexakis, Alexandre Advanced Synthesis and Catalysis, 2010 , vol. 352, # 4 p. 667 - 695

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Citation Number: 70

Abstract

Abstract The purpose of this study is to point out the synthetic utility of a new class of Michael acceptors (nitrodienes and nitroenynes). The highly enantioselective organocatalytic Michael addition of carbonyl compounds to these functionalized nitroolefins has been carried out in the presence of (S)-diphenylprolinol silyl ether to achieve some interesting building blocks in high selectivities. The adducts thus obtained can be easily converted by ...