Synlett

Synthesis of substituted cyclopropylphosphonates by Michael Induced Ring Closure (MIRC) reactions

…, G Van Heecke, C Barbero, K Patora, N De Kimpe…

Index: Stevens, Christian V.; Van Heecke, Gino; Barbero, Carmen; Patora, Krystyna; De Kimpe, Norbert; Verhe, Roland Synlett, 2002 , # 7 p. 1089 - 1092

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Citation Number: 19

Abstract

The alkylidene malonates, alkylidene malonitriles, and alkylidene cyano acetates 3 were prepared by Knoevenagel condensation of an aldehyde and a doubly activated methylene compound 2 (malonate or malonitrile) (Scheme [1] ). When volatile aldehydes were used, a threefold excess was utilized. The Michael acceptors 3 were obtained in high yield (56-93%) after azeotropic removal of water during the reaction. [26] These were then subsequently treated with NBS in ...