Synthetic Communications®

Efficient Arndt–eistert synthesis of selective 5-HT7 receptor antagonist SB-269970

C Schjøth-Eskesen, HH Jensen

Index: Schjoth-Eskesen, Christina; Jensen, Henrik Helligso Synthetic Communications, 2009 , vol. 39, # 18 p. 3243 - 3253

Full Text: HTML

Citation Number: 8

Abstract

Abstract This contribution describes a novel Arndt–Eistert approach for the efficient synthesis of the potent and selective 5-HT7-antagonist,(R)-3-(2-(2-(4-methylpiperidin-1-yl)-ethyl) pyrrolidine-1-sulfonyl) phenol (SB-269970), from d-proline. The synthesis was carried out in 10 steps with an overall yield of 23%.