Efficient Synthesis of 2, 3, 4-Trisubstituted Quinolines via Friedländer Annulation with Nanoporous Cage-Type Aluminosilicate AlKIT-5 Catalyst

S Chauhan, R Chakravarti, SMJ Zaidi, SS Al-Deyab…

Index: Chauhan; Chakravarti; Zaidi; Al-Deyab, Salem S.; Reddy, B. V. Subba; Vinu Synlett, 2010 , # 17 p. 2597 - 2600

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Citation Number: 9

Abstract

Abstract 2-Aminoaryl ketones undergo smooth Friedländer condensation/annulation with α- methyleneketones on the surface of nanoporous aluminosilicate catalyst to afford the corresponding quinoline derivatives in good yields with high selectivity due to its high surface area, large pore volume, and high acidity. The use of highly acidic and reusable AlKIT-5 catalyst makes the Friedländer annulation simple, convenient, and practical.