Asymmetric reduction of 3-hydroxymethylbutenolide derivatives by bakers' yeast: A new approach to the synthesis of factor-I

K Takabe, M Tanaka, M Sugimoto, T Yamada…

Index: Takabe, Kunihiko; Tanaka, Masaya; Sugimoto, Masahisa; Yamada, Takashi; Yoda, Hidemi Tetrahedron: Asymmetry, 1992 , vol. 3, # 11 p. 1385 - 1386

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Citation Number: 27

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Bakers' yeast reduction of 3-benzyloxymethylbutenolide gave (S)-3-benzyloxymethylbutanolide , and its transfomation to Factor-I, the autoregulator of Streptomyces viridocchromogenes, was examined. ... (S)-7: 7% yield, [α] D 23 +22.2 (c0.75,CHCl 3 ) [Lit. 6c,d [α] D 21.5 +44.8 (cl. ...