xenobiotica

Fate of the anthelmintic, phenothiazine, in man

SC Mitchell, P Kestell, GB Steventon, RH Waring

Index: Mitchell; Kestell; Steventon; Waring Xenobiotica, 2002 , vol. 32, # 9 p. 771 - 782

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Citation Number: 3

Abstract

1. Radiolabelled [35 S]-phenothiazine has been administered orally to two healthy adult male volunteers (6mg kg-1 body weight). Faeces were the major route of excretion of radioactivity (68%), the remainder being eliminated via the urine (32%) with an estimated urinary half-life (biphasic) of 6-16 h. Over the 5 days of the study a complete recovery of radioactivity was achieved. 2. From urinary data, it was shown that metabolism occurred ...