Bioorganic & medicinal chemistry

Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein

K Juvale, VFS Pape, M Wiese

Index: Juvale, Kapil; Pape, Veronika F.S.; Wiese, Michael Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 1 p. 346 - 355

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Citation Number: 76

Abstract

Breast cancer resistance protein (BCRP/ABCG2) belongs to the ATP binding cassette family of transport proteins. BCRP has been found to confer multidrug resistance in cancer cells. A strategy to overcome resistance due to BCRP overexpression is the investigation of potent and specific BCRP inhibitors. The aim of the current study was to investigate different multi- substituted chalcones for their BCRP inhibition. We synthesized chalcones and ...