Array-based structure and gene expression relationship study of antitumor sulfonamides including N-[2-[(4-hydroxyphenyl) amino]-3-pyridinyl]-4- …

…, K Yamazaki, K Yoshimatsu, T Yamori…

Index: Owa, Takashi; Yokoi, Akira; Yamazaki, Kanami; Yoshimatsu, Kentaro; Yamori, Takao; Nagasu, Takeshi Journal of Medicinal Chemistry, 2002 , vol. 45, # 22 p. 4913 - 4922

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Citation Number: 47

Abstract

Compounds from sulfonamide-focused libraries have been evaluated in cell-based antitumor screens using the COMPARE analysis with a panel of 39 human cancer cell lines and flow cytometric cell cycle analysis. Thus far, 2 (N-[2-[(4-hydroxyphenyl) amino]-3- pyridinyl]-4-methoxybenzenesulfonamide (E7010)) and 3 (N-(3-chloro-7-indolyl)-1, 4- benzenedisulfonamide (E7070)) have been selected from the collections as potent cell ...