Semiaqueous potentiometric determinations of apparent pKa1 values for benzothiadiazines and detection of decomposition during solubility variation with pH studies

UG Hennig, RE Moskalyk, LG Chatten…

Index: Hennig; Moskalyk; Chatten; Chan Journal of Pharmaceutical Sciences, 1981 , vol. 70, # 3 p. 317 - 319

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Citation Number: 8

Abstract

Abstract Apparent acidity constants obtained for various benzothiadiazine diuretics by semiaqueous potentiometric titrations gave satisfactory agreement with many values obtained by aqueous potentiometry. One suitable method for determining the acidity constants of sparingly soluble drugs, the solubility variation with pH technique, does not take into account instability problems. The preparation of decomposition products and the TLC ...