Anti-AIDS agents. Part 36: 17-carboxylated steroids as potential anti-HIV agents

P Xia, ZY Yang, Y Xia, YQ Zheng, LM Cosentino…

Index: Xia, Peng; Yang, Zheng-Yu; Xia, Yi; Zheng, Yun-Qing; Cosentino, L.Mark; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 9 p. 1907 - 1911

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Citation Number: 15

Abstract

In our search for novel anti-HIV agents, seven 17-carboxylated steroid derivatives were synthesized and evaluated as potential anti-HIV agents. Compound 13 exhibited potent anti- HIV activity in acutely infected H9 lymphocytes with EC50 and therapeutic index values of 0.8 μM and 300, respectively.