Tetrahedron Letters

The direct C–H halogenations of indoles

L Shi, D Zhang, R Lin, C Zhang, X Li, N Jiao

Index: Shi, Leilei; Zhang, Dongmei; Lin, Riyuan; Zhang, Chun; Li, Xun; Jiao, Ning Tetrahedron Letters, 2014 , vol. 55, # 14 p. 2243 - 2245

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Citation Number: 7

Abstract

Abstract A novel and efficient transition metal-free C–H bond halogenation of indole derivatives has been developed. 3-Halogenated (3-Br, 3-I) indoles are highly regioselectively produced by this protocol. Simple and readily available halide salts (TBAB, KI) are employed as the halogen source. The transition metal-free and the mild conditions make this protocol very easy to handle and practical.