4-Functionally Substituted 3-Heterylpyrazoles: VIII. 3-Aryl (heteryl)-4-hydroxyl (chloro) methylpyrazoles

MK Bratenko, VA Chornous, MV Vovk

Index: Bratenko; Chornous; Vovk Russian Journal of Organic Chemistry, 2002 , vol. 38, # 3 p. 411 - 414

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Citation Number: 5

Abstract

Abstract 3-Aryl (heteryl) pyrazole-4-carbaldehydes were reduced with sodium tetrahydridoborate under mild conditions to give 3-aryl (heteryl)-4-hydroxymethylpyrazoles which were converted into the corresponding 4-chloromethyl derivatives by treatment with thionyl chloride. The subsequent reaction with triphenylphos-phine led to formation of triphenyl (4-pyrazolylmethyl) phosphonium chlorides, and Wittig reaction of the latter with ...