Mapping of the active site of rat kidney γ-glutamyl transpeptidase using activated esters and their amide derivatives

R Castonguay, C Lherbet, JW Keillor

Index: Castonguay, Roselyne; Lherbet, Christian; Keillor, Jeffrey W. Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 12 p. 4185 - 4191

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Citation Number: 17

Abstract

The enzyme γ-glutamyl transpeptidase (GGT), implicated in many physiological processes, catalyses the transfer of a γ-glutamyl from a donor substrate to an acyl acceptor substrate, usually an amino acid or a peptide. In order to investigate which moieties of the donor substrate are necessary for recognition by GGT, the structure of the well-recognized substrate l-γ-glutamyl-p-nitroanilide was modified. Several activated esters and their ...