Evaluation of pyrrolidin-2-imines and 1, 3-thiazolidin-2-imines as inhibitors of nitric oxide synthase

…, M MacCoss, JL Humes, SG Pacholok, SK Grant…

Index: Shankaran; Donnelly, Karla L.; Shah, Shrenik K.; Guthikonda, Ravindra N.; MacCoss, Malcolm; Humes, John L.; Pacholok, Stephen G.; Grant, Stephan K.; Kelly; Wong Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 17 p. 4539 - 4544

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Citation Number: 26

Abstract

Syntheses and evaluation of pyrrolidin-2-imines and 1, 3-thiazolidin-2-imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin- 2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity.

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