Tetrahedron

Synthesis and structure of novel cyclonucleoside analogues of uridine

S Zhong, M Mondon, S Pilard, C Len

Index: Zhong, Shi; Mondon, Martine; Pilard, Serge; Len, Christophe Tetrahedron, 2008 , vol. 64, # 33 p. 7828 - 7836

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Citation Number: 14

Abstract

Novel cyclonucleoside analogues of uridine having pentylene and hexylene linker between the 5′-O and 3-N positions (thereby generating a 13-and 14-membered ring, respectively) were synthesized from uridine via ring-closing metathesis. An example of cyclic dinucleosides having two butylene linkers between the 5′-O and 3-N positions (24- membered ring) was synthesized from uridine via tandem cross-metathesis and ring- ...