Synthesis and Antimicrobial Evaluation of Nitazoxanide??Based Analogues: Identification of Selective and Broad Spectrum Activity
TE Ballard, X Wang, I Olekhnovich, T Koerner…
Index: Ballard, T. Eric; Wang, Xia; Olekhnovich, Igor; Koerner, Taylor; Seymour, Craig; Salamoun, Joseph; Warthan, Michelle; Hoffman, Paul S.; Macdonald, Timothy L. ChemMedChem, 2011 , vol. 6, # 2 p. 362 - 377
Full Text: HTML
Citation Number: 12
Abstract
Abstract A library composed of nitazoxanide-based analogues was synthesized and assayed for increased antibacterial efficacy against the pyruvate–ferredoxin oxidoreductase (PFOR) using microorganisms Helicobacter pylori, Campylobacter jejuni and Clostridium difficile. Derivatives were found to recapitulate and improve activity against these organisms and select analogues were tested for their ability to disrupt the PFOR enzyme directly. The ...