An efficient and novel approach for the synthesis of substituted N-aryl lactams

D Chaturvedi, AK Chaturvedi, N Mishra…

Index: Chaturvedi, Devdutt; Chaturvedi, Amit K.; Mishra, Nisha; Mishra, Virendra Organic and Biomolecular Chemistry, 2012 , vol. 10, # 46 p. 9148 - 9151,4

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Citation Number: 3

Abstract

A quick, efficient, one-pot method for the synthesis of substituted N-aryl lactams through the reaction of various kinds of corresponding substituted arenes with a variety of ω-azido alkanoic acid chlorides using a Lewis acid (ie EtAlCl2) at room temperature, through the in situ involvement of a Friedel–Crafts reaction followed by intramolecular Schimdt rearrangement was developed, and afforded good to excellent yields.