Synthesis of 4 (3H)??quinazolinones from derivatives of methyl 2??isothiocyanatobenzoate

WD Dean, EP Papadopoulos

Index: Dean, William D.; Papadopoulos, Eleftherios P. Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 1117 - 1124

Full Text: HTML

Citation Number: 29

Abstract

Abstract Ethyl N-(2-methoxycarbonylphenyl) thiocarbamate (2), N-(2-ethoxycarbonylphenyl)- 4-methoxythiobenz-amide (3b), and 2-(4-methoxyphenyl)-4H-3, 1-benzothiazin-4-one (4a), react with nucleophilic reagents containing at least one primary amino group to yield a variety of 2-substituted and 2, 4-disubstituted 4 (3H) quinazolinones, as well as some tricyclic and tetracyclic products.

Related Articles:

Radical Synthesis of Guanidines from N??Acyl Cyanamides

[Larraufie, Marie-Helene; Ollivier, Cyril; Fensterbank, Louis; Malacria, Max; Lacote, Emmanuel Angewandte Chemie - International Edition, 2010 , vol. 49, # 12 p. 2178 - 2181]

Synthesis of 2, 4-diaminoquinazolines and tricyclic quinazolines by cascade reductive cyclization of methyl N-cyano-2-nitrobenzimidates

[Yin, Ping; Liu, Nan; Deng, Yu-Xing; Chen, Yue; Deng, Yong; He, Ling Journal of Organic Chemistry, 2012 , vol. 77, # 6 p. 2649 - 2658]

Preparation of imidazo [2, 1??b] quinazolin??5 (3H)??ones and related tricyclic systems using a novel, double displacement reaction

[Peet, Norton P.; Malecha, James; LeTourneau, Michael E.; Sunder, Shyam Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 257 - 264]

Preparation of imidazo [2, 1??b] quinazolin??5 (3H)??ones and related tricyclic systems using a novel, double displacement reaction

[Peet, Norton P.; Malecha, James; LeTourneau, Michael E.; Sunder, Shyam Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 257 - 264]

Preparation of imidazo [2, 1??b] quinazolin??5 (3H)??ones and related tricyclic systems using a novel, double displacement reaction

[Peet, Norton P.; Malecha, James; LeTourneau, Michael E.; Sunder, Shyam Journal of Heterocyclic Chemistry, 1989 , vol. 26, p. 257 - 264]

More Articles...