Tandem radical cyclisation-intramolecular Mukaiyama aldolisation approach to forskolin
JH Hutchinson, G Pattenden, PL Myers
Index: Hutchinson, John H.; Pattenden, Gerald; Myers, Peter L. Tetrahedron Letters, 1987 , vol. 28, # 12 p. 1313 - 1316
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Citation Number: 38
Abstract
Summary: The trans-decalin lactone (ll), an advanced intermediate towards forskolin (l), has been elaborated in five steps from the bromo-acetal (4) using a novel stereoselective intramolecular radical mediated cyclisation reaction,*(4)+(5), in tandem with an intramolecular Mukaiyama aldolisation, viz (lO)+(ll).
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