Enzymatic phosphorylation of the antiherpetic agent 9-[(2, 3-dihydroxy-1-propoxy) methyl] guanine

…, J Germershausen, R Bostedor, B Arison…

Index: Karkas; Ashton; Canning; Liou; Germershausen; Bostedor; Arison; Field; Tolman Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 842 - 848

Full Text: HTML

Citation Number: 23

Abstract

JD Karkas,* WT Ashton, L. F. Canning, R. Liou, J. Germershausen, R. Bostedor, B. Arison, AK Field, and RL Tolman Merck Sharp and Dohm. Research Laboratories, Rahway, New Jersey 07065, and West Point, Pennsylvania 19486. Received July 24, 1985 ... The antiherpetic agent 9- [ (2,3-dihydroxy-l-propoxy)methyl]guanine (iNDG) is phosphorylated by HSVl thymidine kinase, and its phosphorylated products inhibit DNA polymerase activity. iNDG exists in ...

Related Articles:

Regioselective opening of simple epoxides with diisopropylamine trihydrofluoride

[Muehlbacher, Manfred; Poulter, C. Dale Journal of Organic Chemistry, 1988 , vol. 53, # 5 p. 1026 - 1030]

Synthesis of isomeric N-(3-fluoro-2-hydroxypropyl) and N-(2-fluoro-3-hydroxypropyl) derivatives of purine and pyrimidine bases

[Jindrich, Jindrich; Dvorakova, Hana; Holy, Antonin Collection of Czechoslovak Chemical Communications, 1992 , vol. 57, # 7 p. 1466 - 1482]

Synthesis of isomeric N-(3-fluoro-2-hydroxypropyl) and N-(2-fluoro-3-hydroxypropyl) derivatives of purine and pyrimidine bases

[Jindrich, Jindrich; Dvorakova, Hana; Holy, Antonin Collection of Czechoslovak Chemical Communications, 1992 , vol. 57, # 7 p. 1466 - 1482]

More Articles...