Ultrasound-mediated synthesis of N, N-bis (phenacyl) aniline under solvent-free conditions

J He, L Shi, S Liu, P Jia, J Wang, R Hu

Index: He, Jingyu; Shi, Lanxiang; Liu, Sijie; Jia, Peng; Wang, Juan; Hu, Ruisheng Monatshefte fur Chemie, 2014 , vol. 145, # 1 p. 213 - 216

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Abstract

Abstract An efficient method for the synthesis of N, N-bis (phenacyl) anilines was developed via smooth condensation of anilines with α-bromoacetophenones in the presence of sodium carbonate as acid acceptor and polyethylene glycol 400 (PEG 400) as catalyst at room temperature under solvent-free conditions by using 350 W ultrasound irradiation. In addition to experimental simplicity, the main advantages of the procedure are mild conditions, short ...