Synthesis and antitubercular activity of styrylquinoxalines

…, LI Lazareva, GS Predvoditeleva, VI Shvedov…

Index: Kartseva, T. V.; Oleshko, O. N.; Lazareva, L. I.; Predvoditeleva, G. S.; Shvedov, V. I.; Filitis, L. N. Pharmaceutical Chemistry Journal, 1987 , vol. 21, # 12 p. 864 - 866 Khimiko-Farmatsevticheskii Zhurnal, 1987 , vol. 21, # 12 p. 1450 - 1453

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Abstract

When (I) is boiled in an excess of acetic anhydride with aromatic aldehydes (p- hydroxybenzaldehyde, 5-bromosalicyZaldehyde, and p-acetylaminobenzaldehyde) in the presence of sodium acetate, the styryl derivatives (ZZ-ZV) are obtained, The hydroxy-group in the 3-position in (ll) and (ZIZ) is readily replaceable by chlorine on treatment with phosphoryl chloride, giving the 3-chloro-2-styrylquinoxalines (V) and (VI),