Tetrahedron

N-Alkoxymethylation of heterocyclic compounds with diethyl phosphite via cleavage of P–O bond

ZJ Quan, RG Ren, XD Jia, YX Da, Z Zhang, XC Wang

Index: Quan, Zheng-Jun; Ren, Rong-Guo; Jia, Xiao-Dong; Da, Yu-Xia; Zhang, Zhang; Wang, Xi-Cun Tetrahedron, 2011 , vol. 67, # 13 p. 2462 - 2467

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Citation Number: 10

Abstract

N-Alkoxymethylation of heterocyclic compounds with diethyl phosphite via cleavage of P–O bond was investigated and a series of N3-ethoxymethylated heterocyclic compounds were synthesized. A mechanism in which diethyl phosphite acts as an efficient surrogate of ethanol was proposed and supported by several evidences.