Tetrahedron Letters

Novel synthesis and γ-alkylation reactions of 4-(1-pyrrolidinyl)-2 (5H)-thiophenones

YJ Li, ZT Liu, SC Yang

Index: Li, Yu-Jang; Liu, Zen-Ting; Yang, Sheng-Chuan Tetrahedron Letters, 2001 , vol. 42, # 45 p. 8011 - 8013

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Citation Number: 8

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Four-step synthesis of achiral and chiral 4-(1-pyrrolidinyl)-2(5H)-thiophenones with 61 and 66% overall yields are described. The γ-alkylation reaction studies and synthetic applications toward the thiolactomycin analog are also reported. ... Methyl acetoacetate 4 in benzene was ...