Enantiodivergent Approach to Trifluoromethylated Amines: A Concise Route to Both Enantiomeric Analogues of Calcimimetic NPS R??568

I Fernández, V Valdivia, A Alcudia…

Index: Fernandez, Inmaculada; Valdivia, Victoria; Alcudia, Ana; Chelouan, Ahmed; Khiar, Noureddine European Journal of Organic Chemistry, 2010 , # 8 p. 1502 - 1509

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Citation Number: 7

Abstract

Abstract Reported herein is a straightforward and enantiodivergent synthesis of both enantiomers of trifluoromethylated analogues of calcimimetic NPS R-569 in a highly estereoselective manner. The synthesis features a diastereoselective synthesis of the N- (isopropylsulfinyl) imine unit by the “DAG methodology” and a diastereoselective addition of Ruppert–Prakash's reagent to the imine as the key steps. No protecting groups were ...