[[. omega.-(Heterocyclylamino) alkoxy] benzyl]-2, 4-thiazolidinediones as potent antihyperglycemic agents

BCC Cantello, MA Cawthorne, GP Cottam…

Index: Cantello, Barrie C.C.; Cawthorne, Michael A.; Cottam, Graham P.; Duff, Peter T.; Haigh, David; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 23 p. 3977 - 3985

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Citation Number: 225

Abstract

benzyl]-2, 4-thiazolidinediones was synthesized from the corresponding aldehydes. Compounds from the urea series, exemplified by 16, showed antihyperglycemic potency comparable with known agents of the type such as pioglitazone and troglitazone (CS-045). The benzoxazole 49, a cyclic analogue of 16, was a very potent enhancer of insulin sensitivity, and by modification of the aromatic heterocycle, an aminopyridine, 37, was ...