Studies on the synthesis of 1-azaspiro [5.5] undecanes related to histrionicotoxin

JJ Venit, M DiPierro, P Magnus

Index: Venit, John J.; DiPierro, Michael; Magnus, Philip Journal of Organic Chemistry, 1989 , vol. 54, # 18 p. 4298 - 4301

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Citation Number: 19

Abstract

3-Methoxybenzaldehyde was converted into 4-(3-methoxyphenyl) butylamine (4), and the derived hydrochloride was reduced with Li/NH3/EtOH to give the spirocyclic keto amine 6. The reduction of 6 and urethane derivatives 13 and 14 to give the corresponding cis and trans alcohols 91 10, 15/16, and 17/18 was studied. The keto amine 6 upon attempted ketalization underwent rearrangement to give the a $-unsaturated imine 11. Treatment of ...

Synthesis and pharmacological characterization of novel 6-fluorochroman derivatives as potential 5-HT1A receptor antagonists

[Yasunaga, Tomoyuki; Kimura, Takenori; Naito, Ryo; Kontani, Toru; Wanibuchi, Fumikazu; Yamashita, Hiroshi; Nomura, Tamako; Tsukamoto, Shin-Ichi; Yamaguchi, Tokio; Mase, Toshiyasu Journal of Medicinal Chemistry, 1998 , vol. 41, # 15 p. 2765 - 2778]

Synthesis and pharmacological characterization of novel 6-fluorochroman derivatives as potential 5-HT1A receptor antagonists

Studies on the synthesis of 1-azaspiro [5.5] undecanes related to histrionicotoxin

Abstract

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