Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors

H Li, J Tatlock, A Linton, J Gonzalez, A Borchardt…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 18 p. 4834 - 4838

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Citation Number: 57

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Further efforts to improve compound enzymatic potency and physical/chemical properties to achieve antiviral activity in the cell-based replicon system will be reported in future communications. Acknowledgments. ...