Design, synthesis and hypolipidemic activity of novel 2-(m-tolyloxy) isobutyric acid derivatives

…, GEDA Abuo-Rahma, OM Aly, MF Radwan

Index: Idrees, Gamal A.; Abuo-Rahma, Gamal El-Din A.; Aly, Omar M.; Radwan, Mohamed F. European Journal of Medicinal Chemistry, 2009 , vol. 44, # 6 p. 2679 - 2684

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Citation Number: 4

Abstract

Novel 2-substituted isobutyric acid derivatives were synthesized and their hypolipidemic activity was evaluated in high cholesterol diet fed rat model. The amide 5a was found to decrease the levels of serum total cholesterol, LDL cholesterol and triglycerides in hyperlipidemic rats to a greater degree than the reference gemfibrozil.