Antimicrobial activities of indolocarbazole and bis-indole protein kinase C inhibitors. II. Substitution on maleimide nitrogen with functional groups bearing a labile …
…, S Fabre, M Sancelme, M Prudhomme, M Rapp
Index: Rodrigues Pereira; Fabre; Sancelme; Prudhomme; Rapp Journal of Antibiotics, 1995 , vol. 48, # 8 p. 863 - 868
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Citation Number: 25
Abstract
New compounds, structurally related to the potent protein kinase C inhibitor staurosporine, and substituted on the imide nitrogen with a functional group bearing a labile hydrogen (hydroxymethyl, amino, hydroxy), were synthesized. Their in vitro inhibitory potencies towards protein kinase C and protein kinase A showed that N-hydroxymethyl and N-hydroxy substitution, unlike alkyl substitution, can provide efficient protein kinase C inhibitors. The ...
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