Synthesis and evaluation of some lipidic aminoalcohols and diamines as immunomodulators

…, A Muro, AR Martínez-Fernández, JJ Nogal-Ruiz…

Index: Olmo, Esther del; Plaza, Alvaro; Muro, Antonio; Martinez-Fernandez, Antonio R.; Nogal-Ruiz, Juan J.; Lopez-Perez, Jose L.; Feliciano, Arturo San Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 6091 - 6095

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Citation Number: 36

Abstract

Lymphoproliferation inhibition and cytotoxicity of a number of lipidic aminoacids, aminoalcohols and diamines were evaluated as a preliminary screening to select potential immunomodulators. The four most potent/less toxic compounds were submitted to delayed hypersensibility (DTH) assays to define the best to be evaluated further Graft-vs-Host, NO production and other immunoevaluation (CD4+, CD45, CD8, CD11b, I-Ek, and NK cells) ...